Hamster (CHO) Cathepsin L - Recombinant

Cathepsin L is a lysosomal cysteine protease with broad-spectrum proteolytic activity, involved in intracellular protein turnover and extracellular matrix remodeling, often correlated with tumor invasion and metastasis.

As a Host Cell Protein (HCP) from Chinese Hamster Ovary (CHO) cells, residual Cathepsin L can co-purify with recombinant therapeutic products and cause fragmentation, impacting their stability, quality, and efficacy.

Due to its secretion and potent degradative ability, Cathepsin L needs to be carefully monitored and efficiently removed during biopharmaceutical manufacturing. High expression levels of Cathepsin L are linked to more aggressive tumors, highlighting the importance of robust downstream purification to ensure product safety and quality.