Cathepsin Z (Host Cell Protein) ELISA Kit – CHO (Chinese Hamster Ovary)

The Cathepsin Z (HCP) ELISA Kit – CHO is a sensitive two‑site immunoassay for detecting Cathepsin Z, a lysosomal cysteine protease involved in intracellular protein turnover, cell adhesion, and cytoskeletal regulation. As a host cell protein released during CHO culture, CTSZ can influence the quality and stability of biologics if not effectively removed during purification. Its cysteine protease activity and role in processing diverse protein substrates make reliable detection essential for robust HCP monitoring.

• Target: Cathepsin L (CTSD)
• Species Reactivity: Hamster (CHO)
• Detection Range: 20 ng/mL – 0.3125 ng/mL
• Sensitivity:
• Assay Time: ~170 minutes
• Sample Type: Tissue culture fluids
• Storage: 2–8°C
• Shelf Life: 1 year
• Application: ELISA

Residual Cathepsin Z is considered a meaningful Host Cell Protein (HCP) impurity due to its proteolytic activity. Even low levels of active Cathepsin Z may contribute to unwanted protein cleavage or structural alterations in therapeutic products, potentially affecting product quality, consistency, and patient safety.